Many chemotherapeutic drugs generate DNA damage that block DNA replication and, or, transcription. This results in cell cycle arrest and apoptosis. However, cancer cells can avoid cell death by a number of mechanisms, whereby DNA repair is one of the most important.
Cisplatin, is used in chemo-therapy to treat e number of tumors. Chlorine anions interact with hydroxy groups (mostly at N7 of purines), forming different types of DNA lesions:
Cisplatin induced DNA adducts block, or slow down, DNA replication and transcription, which corresponds to the “cisplatin induced toxicity”.
(From Carlos Zeladon’s internship, 2011)